Carbidopa with levodopa: In order to prevent conversion of a levodopa into dopamine in the peripheral tissues by Dopa decarboxylase,Levodopa is usually given along with a dopa decarboxylase inhibitor i-e,carbidopa. hence, in this combination most of levodopa remains unchanged and… Continue Reading
Drowsiness Hangover effect Tolerance Withdrawal Effect Dependence and Abuse Rebound insomnia
Aminoglycosdes when used in combination with Furosemide-a loop diuretic cause ear and kidney damage. Risk of ototoxicity and nephrotoxicity increases when aminoglycoside are used in combination with vancomycin,ethacrynic acid or Amphotericin B.
Macrolides, cyclosporine,ketoconazo;e,certain protease inhibitors,nefazodone and fibrates inhibit the metabolism of lovastatin while on the other hand,griseofulvin,phenytoin,barbiturates,rifampicin and thiazildinedions increase the metabolism of lovastatin. Verapamil and amiodarone when used along lovastatin increase the risk of myopathy.
The clearence of ligocaine is reduced and plasma concentration of lignocaine rises by 30% and leads to lignocaine toxicity when administered by propranolol.
ACE inhibitors and Spironolactone: ACE inhibitors cause retention of Potassium in body due to inhibition of aldosterone formation and thus should be used carefully with spironolactone-a potassium sparing diuretic otherwise cause hyperkalemia and result in toxicity and complete heart block.