Aminoglycosdes when used in combination with Furosemide-a loop diuretic cause ear and kidney damage. Risk of ototoxicity and nephrotoxicity increases when aminoglycoside are used in combination with vancomycin,ethacrynic acid or Amphotericin B.
Macrolides, cyclosporine,ketoconazo;e,certain protease inhibitors,nefazodone and fibrates inhibit the metabolism of lovastatin while on the other hand,griseofulvin,phenytoin,barbiturates,rifampicin and thiazildinedions increase the metabolism of lovastatin. Verapamil and amiodarone when used along lovastatin increase the risk of myopathy.
The clearence of ligocaine is reduced and plasma concentration of lignocaine rises by 30% and leads to lignocaine toxicity when administered by propranolol.
ACE inhibitors and Spironolactone: ACE inhibitors cause retention of Potassium in body due to inhibition of aldosterone formation and thus should be used carefully with spironolactone-a potassium sparing diuretic otherwise cause hyperkalemia and result in toxicity and complete heart block.
People who are taking multiple medications for extended periods of times.Patients with renal or hepatic impairments because their metabolism and excretion will be impaired.Determining who will experience an interaction is largely unpredictable because various factors (age, lifestyle, diet, underlying disease)… Continue Reading
A drug interaction is a situation in which a substance usually another drug affects the activity of a drug when both are administered together. This action can be synergistic-when the drug’s effect is increased or antagonistic-when the drug’s effect is… Continue Reading