Side effects of Diazepam and Flurazepam
Drowsiness Hangover effect Tolerance Withdrawal Effect Dependence and Abuse Rebound insomnia
Clinical Resource
Aminoglycosides
Aminoglycosdes when used in combination with Furosemide-a loop diuretic cause ear and kidney damage. Risk of ototoxicity and nephrotoxicity increases when aminoglycoside are used in combination with vancomycin,ethacrynic acid or Amphotericin B.
Lovastatin
Macrolides, cyclosporine,ketoconazo;e,certain protease inhibitors,nefazodone and fibrates inhibit the metabolism of lovastatin while on the other hand,griseofulvin,phenytoin,barbiturates,rifampicin and thiazildinedions increase the metabolism of lovastatin. Verapamil and amiodarone when used along lovastatin increase the risk of myopathy.
Lignocaine and propranolol
The clearence of ligocaine is reduced and plasma concentration of lignocaine rises by 30% and leads to lignocaine toxicity when administered by propranolol.
Drug Interactions
ACE inhibitors and Spironolactone: ACE inhibitors cause retention of Potassium in body due to inhibition of aldosterone formation and thus should be used carefully with spironolactone-a potassium sparing diuretic otherwise cause hyperkalemia and result in toxicity and complete heart block.
Clinical uses of Prostaglandins
Glaucoma Pulmonary Hypertention Male sexual dysfunction Abortion Patent ductus arteriousus Induction of labor Post partum hemorrhage Peptic Ulcer
Who is at risk of Drug interactions?
People who are taking multiple medications for extended periods of times.Patients with renal or hepatic impairments because their metabolism and excretion will be impaired.Determining who will experience an interaction is largely unpredictable because various factors (age, lifestyle, diet, underlying disease)… Continue Reading
Therapeutics
The branch of medicine concerned with the treatment of disease and the action of remedial agents is called as therapeutics.
Pharmacy
A shop or hospital dispensary where medicinal drugs are prepared or sold.
Drug Combination
Amoxicillin is a penicillin antibiotic that fights bacteria in the body while Clavulanate potassium is a beta-lactamase inhibitor that helps prevent certain bacteria from becoming resistant to amoxicillin.So,they are used in combination for a synergetic effect in body.